A NEW APPROACH TO EVALUATE MAGNESIUM STATUS...

A NEW APPROACH TO EVALUATE MAGNESIUM STATUS: DTERMINATION OF EXCHANGEABLE Mg POOL MASSES USING Mg STABLE ISOTOPE.

Revista Magnesium Reserch – volume 15 – ano 2002 Número 3/4; páginas 191-198

Autores:

1) Christine Feillet-Coudray – Centre de Recherche en Nutriotion Humaine d’Auvergne, Unité Maladies
    Métaboliques et Micronutriments, INRA, Theix, 63122 St Genés Champanelle, France.

2) Charles Coudray - Centre de Recherche en Nutriotion Humaine d’Auvergne, Unité Maladies Métaboliques
    et Micronutriments, INRA, Theix, 63122 St Genés Champanelle, France.

3 )Elyett Gueux - Centre de Recherche en Nutriotion Humaine d’Auvergne, Unité Maladies Métaboliques et
    Micronutriments, INRA, Theix, 63122 St Genés Champanelle, France.

4) Andrzej Mazur - Centre de Recherche en Nutriotion Humaine d’Auvergne, Unité Maladies Métaboliques et
    Micronutriments, INRA, Theix, 63122 St Genés Champanelle, France.

5) Yves rayssinguier- Centre de Recherche en Nutriotion Humaine d’Auvergne, Unité Maladies Métaboliques
    et Micronutriments, INRA, Theix, 63122 St Genés Champanelle, France.
 

Summary:

Magnesium (Mg) status is difficult to evaluate using conventional status markers. Radioactive isotopes and, less commonly, stable isotopes have been used as research tools to assess the size of the exchangeable pools of minerals as a new approach to evaluate mineral status. The present paper is a report concerning the exploration of exchangeable Mg pool characteristics with the use of radioactive and stable isotopes and its validation as a method to evaluate Mg status. Recent data obtained in our laboratory using stable isotopes of Mg in animals and humans are presented. Animal studies demonstrated clearly that the exchangeable Mg pools is an interesting approach to evaluate Mg status, as the size of Mg pool 1,2 and 3 decreased in proportion to Mg deficiency. however more studies are still necessary to better appreciate the relationship between Mg status and exchangeable Mg pool size in humans.