EFFECT OF MAGNESIUM ON GRANULOCYTE...

EFFECT OF MAGNESIUM ON GRANULOCYTE FUNCTION AND ON THE EXERCISE INDUCED INFLAMMATORY RESPONSE.

Revista Magnesium Reserch – volume 16 – ano 2003 Número 1; páginas 49- 58.
 

Autores:

 1)F.C. Mooren – Department of Sports Medicine Westfalische Wilhelms-Universitat Muster, 48129 Munster.
 2)S.W. Golf Institute of Clinical Chemistry, Justus – Liebig – Universitat Gieben, Germany.
 3)K. Volker - Department of Sports Medicine Westfalische Wilhelms-Universitat Muster, 48129 Munster.
 

Summary:

Magnesium Status is a well-Known modulator of the immune system. In the present study was investigated the effect of magnesium on granulocyte signaling and function. Furthermore, we performed a double-blinded randomized study investigating the effect of a two-month magnesium supplementation period on the exercise – associated alterations In immune function. In vitro incubation of granulocytes in media of different magnesium magnesium composition resulted in significant changes in chemotactic peptide-induced calcium transients while basal calcium levels were not affected. Likewise, the stimulus-induced formation of free radicals was affected. In the second part of the study we investigated whether a two-month period of magnesium supplementation was able to diminish alterations in immune system as indicated by an increase induced an activation of the immune system as indicated by an increase in granulocyte count and a post-exercise lymphopenia. In addition, chemotactic peptide-induced cellular calcium transients were enhanced post-exercise while oxidative burst and phagocytosis were decreased. These results suggest that magnesium is an important modulator of immune cell function in the athletes with balanced magnesium status.