IMPORTANCE OF THE RATIO BETWEEN IONIZED AND TOTAL Mg...

IMPORTANCE OF THE RATIO BETWEEN IONIZED AND TOTAL Mg IN SERUM OR PLASMA : NEW DATA ON THE REGULATION OF Mg STATUS AND PRACTICAL IMPORTANCE OF TOTAL Mg CONCENTRATION IN THE INVESTIGATION OF Mg IMBALANCE.
Revista Magnesium Reserch – volume 15 – ano 2002 Número 3/4; páginas 203 – 205.

Autores:

1)J. Durlach – SDRM, UPMC, Paris VI, F-75252 Paris Cédex, France.

2)N. Pagés – Lab. de Toxicologie, Fac de Pharmacie, F-67400 Illkirsh-Graffenstadden, France.

3)P. Bac M. Bara – Lab. de Pharmacologie, Fac. de Pharmacie, Paris XI, F-92290 Chatenay- Malabry,
    France.

4)A. Guiet-Bara- SDRM, UPMC, Paris VI, F-75252 Paris Cédex, France.
 
Summary:

That is an inverse relationship between Mg balance and the ratio ionized Mg/total Mg in serum or plasma: in Mg excess, the ratio is decreased and in Mg deficiency the ratio is increased.
It works as if a subtle homeostatic compensatory reaction modified the proportion of the most biological active fraction of blood Mg in order to reduce the effects of Mg imbalance.
Easy, available and unexpensive, the evaluation of total Mg in plasma or serum appears as a better marker that ionized Mg in Mg imbalance: it should be privileged as the initial investigation in clinical practice.