IS MAGNESIUM DEFICIT IN LYPHOCYTES A PART OF MITRAL VALVE...

IS MAGNESIUM DEFICIT IN LYPHOCYTES A PART OF MITRAL VALVE PROLAPSE SYNDROME?

Revista Magnesium Reserch – volume 17 – ano 2004 Número 1; páginas 39 – 45.

Autores: 

1) Mariusz Kitlinski – Department of Cardiology, University of Lund, Malmo University Hospital MAS, Malmo
    Sweden. 

2)Marek Stepniewski – Radioligand Laboratory, Faculty of Pharmacology, Jagiellonian University, Croacow,
    Poland.

3)Jadwiga Nessler – Department of Coronary Disease, Jagiellonian University, Croacow, Poland.

4)Ewa Konduracka - Department of Coronary Disease, Jagiellonian University, Croacow, Poland.

5)Katarzyna Solarska - Radioligand Laboratory, Faculty of Pharmacology, Jagiellonian University, Croacow,
    Poland.

6)Wielawa Piwowarska - Department of Coronary Disease, Jagiellonian University, Croacow, Poland.

7)Leif Erhardt  - Department of Cardiology, University of Lund, Malmo University Hospital MAS, Malmo
    Sweden. 
 

Summary:

 Magnesium deficiency has been proposed to be related to the mitral valve prolapse syndrome. However determinations of magnesium concentration in blood serum and hemolysates of red blood cells in this disease revealed divergent results. We investigated 49 patients with the mitral valve prolapse syndrome and 30 healthy individuals, matched by age and gender. The concentration of magnesium was measured in the blood plasma and lysates of lymphocytes isolated from venous blood. The magnesium concentration in plasma was similar in both patients and the healthy controls. By contrast, the magnesium concentration in lysates of lymphocytes was significantly lower (p<0.0.3) in the patients with mitral valve prolapse syndrome than in the controls (range: 1.94-10.6 mmol/g of protein in lymphocyte lysate; median 5.98 and 6.7 -9.61 mmol/g of protein, median 7.22).The results obtained suggest that magnesium deficiency may be part of the mitral valve prolapse syndrome.