LOWER WHOLE BLOOD IONIZED MAGNESIUM CONCETRATIONS...

LOWER WHOLE BLOOD IONIZED MAGNESIUM CONCETRATIONS IN HYPOCALCEMIC INFNTS OF GESTATIONAL DIABETIC MOTHERS.

Revista Magnesium Reserch – volume 16 – ano 2003 Número 2; páginas 127- 130.
 

Autores:

1)Sanjoy Banerjee – Department of Pediatrics, Maimonides Childrens Center, 977, 48^th  street, Brooklyn  
    NY 11219, USA.

2)Francis B. Mimouni – Neonatology, Lis Maternity Hospital, 6 Weitzman street, Tel Aviv 64239, Israel.

3)Mimouni - Department of Pediatrics, Maimonides Childrens Center, 977, 48^th  street, Brooklyn NY 11219,
    USA.

3)Rajeev Mehta - Department of Pediatrics, Maimonides Childrens Center, 977, 48^th  street, Brooklyn NY
    11219, USA.

4)Adolfo Llanos - Department of Pediatrics, Maimonides Childrens Center, 977, 48^th  street, Brooklyn NY
    11219, USA.

5)Ronald Bainbridge - Department of Pediatrics, Maimonides Childrens Center, 977, 48^th  street, Brooklyn
    NY 11219, USA.

6)Koteswar Varada - Department of Pediatrics, Maimonides Childrens Center, 977, 48^th  street, Brooklyn
    NY 11219, USA.

7)Galit Sheffer – Department of Obstetrics & Ginecology, Lis Maternity Hospital, 6 Weitzman street, Tel
    Aviv 64239, Israel.


Summary:

infants of insulin dependent (class B and above) diabetic mothers (IDM’s) have a high rate of neonatal hypocalcemia (NHC) and hypomagnesemia. We carried out this study to test the hypotheses that: (1) infants of gestational diabetic (class A) mothers (IGDM’s) are also at risk for NHC and (2) NHC in IGDM’s relates to decrease whole blood Mg2+ concentration. Thirty one term infants born to gestational diabetic mothers of classes Al (diet controlled, n=23) and A2 (requiring insulin, n=8) of White’s classification, were compared at 24 more or less 2 hours of age to 32 healthy, appropriate for gestational age controls, born after uncomplicated pregnancy, labor and delivery. Whole blood Mg2+ and Ca2+ were measured using an ion – specific electrode (Nova 8, Nova Biomedical, Waltham, MA). The rate of NHC was higher in the IGDM group as compared to the control group (9 out of 31 [29%] vs. 1 out of 32 [3.1%] infants; (p< 0.01).Wole blood Mg2+ was lower in the IGDM group than in controls (p<0.05). In multiple regression analysis, when Ca2+ was used as the dependent variable and Mg2+ , diabetes class, gestational age, macrosomia and one minute Apgar scores were the independent variables, only Mg2+ and diabetes class were significant (R2=0.4374; p< 0.01). Our results are consistent with the theory that Mg deficiency plays a role in NHC encountered in IGDM’s, similar to what occurs in infants of insulin-dependent diabetic mothers.