RELATIONSHIP BETWEEN HYPERMAGNESAEMIA IN PRETERM LABOUR...

RELATIONSHIP BETWEEN HYPERMAGNESAEMIA IN PRETERM LABOUR AND ADVERSE HEALTH OUTCOMES IN BABIES.
Revista Magnesium Reserch – volume 15 – ano 2002 Número 3/4; páginas 253- 260.

Autores:

1)Robert Mittendorf – Department of Obstetrics and Gynecology, Loyola university Medical Center,
    Maywood, IL, USA.

2)Peter G. Pryde – Division of Maternal- Fetal Medicine, Department of Obstetrics and Gynecology,
    University of Wisconsin, Madison, WI, USA. 

3)Ronald J. Elin – Departament of Pathology and Laboratory Medicine, University of Louisville School of
    Medicine, Lousville, KY, USA.

4)John G. Gianopoulos - Department of Obstetrics and Gynecology, Loyola university Medical Center,
    Maywood, IL, USA.

5)Kwang-Sun Lee – Section of Neonatology, Department of Pediatrics, University of Chicago, Chicago, IL,
    USA.
 
Abstract:
The Magnesium and Neurology Endpoints Trial (the so-called MagNET Trial) was a randomized clinical trial that was undertaken to establish whether the antenatal usage of magnesium sulphate could protect neonates from having adverse neurology outcomes. Unfortunately, the trial was suspended after 15 months of enrolment because of excess total pediatric mortality among those exposed magnesium sulphate. Following our original report and contrary to the original hypotheses, additional analyses of our data have actually shown a statistically significant increase in the risk of neonatal intraventricular hemorrhage, as well as total adverse paediatric outcomes, among those with higher levels of ionized magnesium at delivery. Nonetheless, it has been postulated, but not established, that anions of magnesium other than sulphate could have a more benign, or even beneficial, effect of health outcomes in the neonate.